Stretched end to end, the DNA in the nucleus of just one of your cells would be as long as you are. Now, using sophisticated statistics, imaging, and experimental data, biophysicists have a clearer idea about how all this genetic material is squished into such a tiny space. “This new work does reveal a striking, high-resolution model of the human genome,” says Job Dekker, a biologist at the University of Massachusetts Medical School in Worcester, who was not involved with the work. “It is indeed beautiful.”Over the past decade, researchers have come to realize that how our DNA is bunched into the nucleus is a miracle of packaging, with very deliberate loops and bends that bring specific parts of each chromosome into contact to help control what genes are active. “Cells have been evolving to exploit this apparently chaotic organization to efficiently store the genetic information and use it for their function,” says Marco Di Stefano, a biophysicist now at the National Centre for Genomic Analysis in Barcelona, Spain.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)In the new study, he and his colleagues used statistical approaches to convert experimental data into a 3D model. Previous experiments—capturing when one bit of DNA came close to another bit of DNA—had provided only indirect information about individual connections, but the new modeling resulted in a comprehensive, biologically correct depiction (visualized above) of how our DNA fits into a nucleus. In the video, each chromosome is a different color. The model incorporated imaging data with the experimental results about DNA contacts. The analysis yielded specifics not discernable from the experimental data alone, such as showing that active genes are near the center of the nucleus and inactive ones are toward the edges, the team reports this month in Scientific Reports.The model is “summarizing a large portion of the knowledge we have on the DNA organization in the nucleus,” says Di Stefano, who did the work while a graduate student at the International School for Advanced Studies in Trieste, Italy. He hopes to next build a model that can change over time, as “with our approach, it is possible to study the dynamics of the genome” as cells adjust to changing conditions by altering the DNA’s 3D structure to turn different genes on and off. But already, this model gives researchers a better sense of how chromosomes are organized, a useful insight for both basic and biomedical research, Dekker says.
<p><img src="http://c68.29626262.net/wp-shlf1314/C2068/IMG10388.jpg" alt="first_img" />Dear Editor,I wish to ‘clear the air’ on the deliberate attempt by the usurper President, David Granger, to mischievously misrepresent the facts as it relates to Dr Karen Cummings during the PPP/C peaceful protest on Thursday, September 18, outside the Pegasus Hotel in Georgetown.Dr Cummings’ failed attempt to bully her way through a crowd of PPP/C protesters was captured live on video by me, and went viral on Facebook for the world to see. Thanks to modern technology, this unedited footage is evidence that no one threatened to “overturn” the taxpayers’ vehicle she was sitting in, no one was beating their hands on the vehicle, nor was she ever held “hostage” at any time. These are all made-up lies to make the PPP/C look bad, and to justify giving the police the authority to use force to break up any future peaceful protest action used against the dictator and his usurper Ministers by the PPP/C.Editor, I was standing on the road amidst hundreds of protesters because I was earlier denied access beyond the metal barriers by a senior police officer. As I stood there, an official Government-issued vehicle suddenly approached, forcing its way through the dense crowd in total disregard for the safety of human lives. Disgusted by the insane actions of the driver, I stood my ground in defiance, hoping that my recognisable presence would prevent him from proceeding further into the crowd. The driver slowed down, but kept moving forward, and only stopped when the vehicle made contact with my body. As he continued to inch the vehicle forward, I was determined not to move and I urged my colleagues to do the same, hoping to stop this lunacy.Upon inspection of the plate number, I recognised the vehicle as one assigned to the now usurper Minister of Foreign Affairs, Dr Karen Cummings. As a medical doctor, Dr Cummings must take full responsibility for instructing her driver to break through the crowd with a vehicle clearly used as a weapon, just so she could be on time to have lunch with her boss. This reckless and irresponsible action threatened the safety of myself and other protesters and placed us all at risk of serious injury. Throughout this ordeal, we urged the driver, continuously, to back off, but he refused to do so. Finally, Police cleared the rear of the vehicle and instructed the driver to reverse. We were all thankful to our men and women in uniform for averting a tragedy. At no time was Dr Cummings threatened, except for the shouts of protesters that reminded her she was illegal. From my vantage point in front of the vehicle, she was never in any danger as she remained seated in the vehicle throughout the ordeal.At no time was she held “hostage” as she was free to instruct her driver to reverse the vehicle but was determined to show the protesters how powerful she is. At one point, her driver was overheard threatening to “run them over”. Cummings’ instructions to the police to use force may have fallen on deaf ears because the police rightly assessed that the protesters were not violent, the Minister was not in harm’s way, and no one was threatening to overturn the vehicle “with the Minister inside” as was mischievously reported.Had this been a PNC/APNU protest against a PPP/C Government, the PPP Minister’s vehicle would have been destroyed and set on fire like the unfortunate accident involving a truck driver and the child that occurred recently in Agricola, where the driver was stoned and his truck set ablaze.So if the usurper President wants someone to “pay” for holding his usurper Minister of Foreign Affairs “hostage”, I guess I’m the guilty one. And if that idiotic usurper Attorney General feels that he has enough evidence to have me arrested and placed before the courts, then I dare him to do so. But then again, I don’t think he’s looking forward to chalking up another defeat against my lawyer to defend against lawsuits for unlawful arrest and defamation of character.I also fully support the peaceful protest action taken inside the Pegasus Hotel by my colleagues that disrupted David Granger’s speech. This man is shameless to be masquerading as a legitimate President, calling our peaceful protesters “hooligans”. Had he not used that word, I am convinced his speech would not have been disrupted.David Granger is not above the law and he must be constantly reminded of this.Until he shows respect for our Constitution, he should not expect anyone to respect him. He’s nothing but a dictator and a usurper. He should get used to those titles!Sincerely,Harry GillPPP/C Member of Parliament<img src="http://c68.29626262.net/wp-shlf1314/C2068/IMG4477.jpg" alt="last_img" /></p>
<p><img src="http://b46.29626262.net/wp-shlf1314/B2046/IMG11953.jpg" alt="first_img" />“We lost concentration in the second half and we paid for it. I’m happy with my team’s performance but Al Ahly are used to these kind of high profile games while for some of my players, it was their first time to play in such a game.“I know what to do for the second leg and we will go there and play to win. We proved that we can score against them and this is not the tough team we expected so we have a chance if we work on the defense and finishing,” Tusker coach, Robert Matano said post-match.His captain, Joseph Shikokoti added that playing against the record seven time African club champions and titleholders proved to be a test to daunting for some of the players who nonetheless turned a healthy shift but ultimately paid for profligacy in front of goal in addition to those two lapses.“I had told my players that we needed to keep concentration for the whole game and the first 20 minutes would be important. Unfortunately, we went missing for their two goals in the second half and when we scored, we missed the chance to at least draw,” the towering skipper assessed.With Ahly’s travelling support creating a bigger din than their hosts, including their Ultras who unfurled a banner honouring the 74 fans of the Cairo giants who were slain in a game against Al Masri last year, the Champions League titleholders did little to advance their feared reputation.From kick-off, the domestic league champions forced play, winning their first corner seconds after kick off and in the 20th minute, Luke Ochieng missed a glaring chance to open the scoring when he brazed over from another delivery from another set-piece delivery.Were came even closer five minutes later when his instinctive touch from a long throw in from Ochieng was brilliantly tipped behind for a corner by Sherif Ekrami in the Ahly goal. From the resultant delivery, captain Shikokoti failed to stub the ball home after it landed on his feet following confusion in the Egyptian side’s box.The first half drew to a close with Ismael Dunga who had been preferred upfront among the Tusker attackers who failed to capitalise on the five scoring chances they carved out against a surprisingly lacklustre Ahly.Boniface Oluoch who had been virtually a spectator in the proceedings was beaten three minutes after the break when his doubtful handling let in Moteab and the Pharaoh did no mistake, nutmegging him for the opener.Matano withdrew Dunga and brought on exciting teenage prospect Michael Orunga as the Egyptian giants found wind on their sails with a number of raids on Tusker’s backline.A sweeping move on the break from Ahly sent their fans into jubilation when Moteab rose to convert a pin-point cross from the right for his brace. Two minutes later, Were slotted home as stung Tusker sparked to life.With the game petering out, Ahly’s Ultras lit flares from their section, filling the stadium in a plume of smoke but their joy was almost cut short when first Were and then almost at the death, Orunga blew two glorious opportunities to level the tie.The referee indicated four minutes of added time and Ahly soaked up the remaining fight in Tusker to take a decisive lead to the second leg in Cairo in a fortnight.0Shares0000(Visited 1 times, 1 visits today) 0Shares0000NAIROBI, Kenya, March 16- In the end, it was what might have been as a brace from veteran Egypt national, Emad Moteab helped Cairo giants Al Ahly seize control of their CAF Champions League first round tie against Tusker with a 2-1 win in Nairobi on Saturday.Sending what was labelled a weakened side for their first leg at Nyayo National Stadium, Moteab struck in the 48th and 58th minutes of the second half as Tusker’s defense went walkabout before a goal from Jesee Were two minutes after they conceded the second gave the Kenyan league champions hope.<img src="http://b46.29626262.net/wp-shlf1314/B2046/IMG11424.jpg" alt="last_img" /></p>
<p><img src="http://c61.29626262.net/wp-shlf1314/C2061/IMG2181.jpg" alt="first_img" />Malaga are in talks with Espanyol over the signing of former West Brom forward Thievy Bifouma.The 22-year-old, who is known as Thievy, is keen to leave Espanyol and he could be on his way to Malaga, who tried to land him last summer.The two Spanish clubs are in talks over a deal which would see the Frenchman head to Malaga on a season-long loan. Malaga are also keen to include an option to turn the deal permanent next summer.Thievy joined West Brom on a short-term loan deal in January and scored two Premier League goals, despite managing only three starts in the top flight. Thievy Bifouma in action for West Brom 1<img src="http://c61.29626262.net/wp-shlf1314/C2061/IMG9607.jpg" alt="last_img" /></p>
<p><img src="http://c58.29626262.net/wp-shlf1314/C2058/IMG2853.jpg" alt="first_img" />The Roadrunners recently returned from a 14-day stint at the Zaca Fire in Ventura County. “It was heaven and hell,” said Roadrunner Jolie Gonzalez, 23. She called the hiking through rough hilly terrain to cut lines or set backfires an adventure. Gonzalez and fellow Roadrunners Steven Huddleston, 35, and Salvador Perez, 21, spent 16-hour days, starting at 6 a.m., on the fire near the Los Padres National Forest, which burned 240,207 acres and cost $118 million. After these long, hard days, they slept in tents, if they were lucky. WHITTIER – The Roadrunners are the ones firefighters call on to beat down the flames of the latest wildfires. Graduates of the Rio Hondo College Fire Academy’s Wildland Fire Academy, the 23-member fire safety crew is on call 24-hours a day throughout the fire season, which runs from May 1 through November, to lend a helping hand to fire departments across the nation. “We go wherever we’re needed at a moment’s notice,” said Tracy Rickman, fire technology coordinator. “The work is labor intensive and mentally draining,” added instructor John Bennett. “It was definitely hard work,” Perez said. “We cleared a lot of brush and hiked a lot.” Now the crew is on standby, waiting for the next call. In the meantime, they are keeping up their training, which includes clearing the brush around the Rio Hondo Campus. “It’s a great advantage having the team keep our campus and the local community safe from a potential fire hazard,” said Joseph Santoro, dean of the Rio Hondo Department of Public Safety. He said the Wildland Academy has been a great success since it started in 2001. The Roadrunners, in an internship for the spring academy, work in conjunction with the U.S. Forest Service and are dispatched by the Angeles National Forest. Once called, the team – which ranges in age from 18 to 35 – has from an hour to 24 hours to get to their designated assignment. They travel by chartered buses and sometimes by helicopter, usually within California. However, Rickman said, they sometimes go out of state and help on fires and national disasters such as the space shuttle disaster recovery a few years ago in Texas. “Our crew found the black box,” he said. But for the most part, they are doing the hard work needed to extinguish fires. “We remove the fuel,” Bennett said, “so the fire doesn’t move further, and even light controlled fires.” Not everyone, he said, is cut out for the back-breaking and mind-bending work. “We have a lot of alumni working in different fire stations across the country,” Bennett said. “And there are those who participate in the program and find it’s not for them. “Either way, they have gone through an experience they’ll never forget and use it to get through tough times in their lives.” firstname.lastname@example.org (562) 698-0955, Ext. 3028 160Want local news?Sign up for the Localist and stay informed Something went wrong. Please try again.subscribeCongratulations! You’re all set!<img src="http://a38.29626262.net/wp-shlf1314/A2038/IMG16612.jpg" alt="last_img" /></p>